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Article

A targeted amplicon next-generation sequencing assay for tryptase genotyping to support personalized therapy in mast cell-related disorders.

PloS one - 1 Jan 2024

Li Olga, Hackney Jason A, Choy David F, Chang Diana, Nersesian Rhea, Staton Tracy L, Cai Fang, Toghi Eshghi Shadi

Abstract excerpt

Tryptase, the most abundant mast cell granule protein, is elevated in severe asthma patients independent of type 2 inflammation status. Higher active β tryptase allele counts are associated with higher levels of peripheral tryptase and lower clinical benefit from anti-IgE therapies. Tryptase is a therapeutic target of interest in severe asthma and chronic spontaneous urticaria. Active and inactive allele counts...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38335181
DOI: 10.1371/journal.pone.0291947
PMCID: PMC10857577

Genes

TPSAB1
TPSB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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