Article
Ulcerative colitis is associated with a promoter polymorphism of lipopolysaccharide receptor gene, CD14.
Scandinavian journal of gastroenterology - 1 Jun 2002
Obana N, Takahashi S, Kinouchi Y, Negoro K, Takagi S, Hiwatashi N, Shimosegawa T
Abstract excerpt
BACKGROUND: Inflammatory bowel disease (IBD) is a multifactorial disease with a significant genetic background. Evidence is accumulating that molecules such as CD14, which interact with luminal bacterial constituents, are involved in the pathogenesis. It has recently been shown that the T allele of the 5'-flanking region of the CD14 gene at position -159 is related to high expression of CD14. In further exploring...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.