Article
Association between Toll-like receptor 4 and inflammatory bowel disease.
Inflammatory bowel diseases - 1 Jun 2005
Oostenbrug Liekele E, Drenth Joost P H, de Jong Dirk J, Nolte Ilja M, Oosterom Elvira, van Dullemen Hendrik M, van der Linde Klaas, te Meerman Gerard J, van der Steege Gerrit, Kleibeuker Jan H, Jansen Peter L M
Abstract excerpt
BACKGROUND: The human Toll-like receptor 4 (TLR4) participates in the innate response. Recently, the TLR4 variant Asp299Gly has been described to affect the response of this receptor to lipopolysaccharide. As such, there is a potentially important role of TLR4 in the pathogenesis of inflammatory bowel disease (IBD). We studied the involvement of TLR4 in IBD in a large population of Dutch patients with IBD and in...
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