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Article

The c.1-260C>T promoter variant of CD14 but not the c.896A>G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease.

Digestion - 1 Jan 2007

Baumgart Daniel C, Buning Carsten, Geerdts Lars, Schmidt Hartmut H, Genschel Janine, Fiedler Thomas, Gentz Enno, Molnar Tomas, Nagy Ferenc, Lonovics Janos, Lochs Herbert, Wiedenmann Bertram, Nickel Renate, Witt Heiko, Dignass Axel

Abstract excerpt

BACKGROUND: Inflammatory bowel disease (IBD) results from an aberrant immune response to the indigenous intestinal flora in genetically susceptible hosts. Therefore, the study of candidate genes involved in host pathogen interactions is of key interest. METHODS: In this two-center, retrospective German and Hungarian cohort study, patients with Crohn's disease (CD) (n = 379; German n = 235, Hungarian n = 144) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Inflammatory Bowel Diseases

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Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Share to Toll-Like Receptor 4

Source

Identifiers

PMID: 18174680
DOI: 10.1159/000112646

Genes

TLR4
NOD2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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The c.1-260C>T promoter variant of CD14 but not the c.896A>G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease.PMID 18174680Read ↗

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A polymorphism in the CD14 gene is associated with Crohn disease.Semantic proximity Read ↗

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NOD1 gene E266K polymorphism is associated with disease susceptibility but not with disease phenotype or NOD2/CARD15 in Hungarian patients with Crohn's disease.Semantic proximity Read ↗

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