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Article

pH-dependent modulation of Kv1.3 inactivation: role of His399.

American journal of physiology. Cell physiology - 1 Oct 2004

Somodi Sándor, Varga Zoltán, Hajdu Péter, Starkus John G, Levy Daniel I, Gáspár Rezso, Panyi György

Abstract excerpt

The Kv1.3 K(+) channel lacks N-type inactivation, but during prolonged depolarized periods it inactivates via the slow (P/C type) mechanism. It bears a titratable histidine residue in position 399 (equivalent of Shaker 449), a site known to influence the rate of slow inactivation. As opposed to several other voltage-gated K(+) channels, slow inactivation of Kv1.3 is slowed when extracellular pH (pH(o)) is lowered...

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Identifiers

PMID: 15201143
DOI: 10.1152/ajpcell.00438.2003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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