Article
Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels.
Receptors & channels - 1 Jan 1993
López-Barneo J, Hoshi T, Heinemann S H, Aldrich R W
Abstract excerpt
After removal of N-type inactivation in Shaker K channels another inactivation process remains (C-type inactivation). The C-type inactivation time course is reversibly slowed when external [K+] increases. The effect of K+ is mimicked by Rb+ and, with less potency, by the less permeant ions Na+, Cs+, and NH4+. These results, which can be explained by the foot-in-the-door model of gating, could reflect the variable...
Topics
- Animals
- Cations, Monovalent
- Female
- In Vitro Techniques
- Kinetics
- Membrane Potentials
- Mutagenesis, Site-Directed
- Mutation
- Oocytes
- Potassium Channel Blockers
- Potassium Channels