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Article

A direct demonstration of closed-state inactivation of K+ channels at low pH.

The Journal of general physiology - 1 May 2007

Claydon Thomas W, Vaid Moni, Rezazadeh Saman, Kwan Daniel C H, Kehl Steven J, Fedida David

Abstract excerpt

Lowering external pH reduces peak current and enhances current decay in Kv and Shaker-IR channels. Using voltage-clamp fluorimetry we directly determined the fate of Shaker-IR channels at low pH by measuring fluorescence emission from tetramethylrhodamine-5-maleimide attached to substituted cysteine residues in the voltage sensor domain (M356C to R362C) or S5-P linker (S424C). One aspect of the distal S3-S4...

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Identifiers

PMID: 17470663
DOI: 10.1085/jgp.200709774
PMCID: PMC2154379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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