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Article

Regulation of N- and C-type inactivation of Kv1.4 by pHo and K+: evidence for transmembrane communication.

American journal of physiology. Heart and circulatory physiology - 1 Jan 2003

Li Xiaoyan, Bett Glenna C L, Jiang Xuejun, Bondarenko Vladimir E, Morales Michael J, Rasmusson Randall L

Abstract excerpt

Kv1.4 encodes a slowly recovering transient outward current (I(to)), which inactivates by a fast N-type (intracellular ball and chain) mechanism but has slow recovery due to C-type inactivation. C-type inactivation of the NH(2)-terminal deletion mutant (fKv1.4DeltaN) was inhibited by 98 mM extracellular K(+) concentration ([K(+)](o)), whereas N-type was unaffected. In 98 mM [K(+)](o), removal of intracellular...

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Identifiers

PMID: 12388308
DOI: 10.1152/ajpheart.00392.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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