Constitutive inactivation of the hKv1.5 mutant channel, H463G, in K+-free solutions at physiological pH.

Abstract excerpt

Extracellular acidification and reduction of extracellular K(+) are known to decrease the currents of some voltage-gated potassium channels. Although the macroscopic conductance of WT hKv1.5 channels is not very sensitive to [K(+)](o) at pH 7.4, it is very sensitive to [K(+)](o) at pH 6.4, and in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Body Fluids
• Share to Extracellular Fluid
• Share to Hydrogen-Ion Concentration