Article
Interleukin-10 promoter polymorphisms and atopic asthma in North Indians.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jul 2005
Chatterjee R, Batra J, Kumar A, Mabalirajan U, Nahid S, Niphadkar P V, Ghosh B
Abstract excerpt
BACKGROUND: IL-10 is an anti-inflammatory cytokine primarily produced by monocytes and macrophages and plays a key role in asthma. IL10 gene, present in chromosome 1q31-q32, is regulated primarily by transcription and its expression is found to be lower in asthmatics. Earlier studies in diverse populations have identified several promoter polymorphisms. However, no study has been carried out in a genetically...
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