Article
Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q.
Human molecular genetics - 15 Aug 2004
Paunio Tiina, Tuulio-Henriksson Annamari, Hiekkalinna Tero, Perola Markus, Varilo Teppo, Partonen Timo, Cannon Tyrone D, Lönnqvist Jouko, Peltonen Leena
Abstract excerpt
Research to identify predisposing genes for complex diseases relying solely on clinical diagnosis is probably not ideal. Here, we analyzed genome-wide data for 168 schizophrenia families using neuropsychological variables associated with disease susceptibility, with the aid of SOLAR, a program for variance-component analysis. The linkage signal was greatly accentuated by application of the quantitative traits...
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