Article
Impaired intellect and memory: a missing link between genetic risk and schizophrenia?
Archives of general psychiatry - 1 Sept 2010
Toulopoulou Timothea, Goldberg Terry E, Mesa Irene Rebollo, Picchioni Marco, Rijsdijk Fruhling, Stahl Daniel, Cherny Stacey S, Sham Pak, Faraone Stephen V, Tsuang Ming, Weinberger Daniel R, Seidman Larry J, Murray Robin M
Abstract excerpt
CONTENT: The DSM-IV concept of schizophrenia offers diagnostic reliability but etiologic and pathologic heterogeneity, which probably contributes to the inconsistencies in genetic studies. One solution is to identify intermediate phenotypes, "narrower" constructs of liability, that hypothetically share genetic risk with the disorder. Although a variety of candidate intermediate phenotypes have emerged, few have...
Topics
- Adult
- Cognition Disorders
- Diagnostic and Statistical Manual of Mental Disorders
- Diseases in Twins
- Family
- Female
- Genetic Predisposition to Disease
- Humans
- Intellectual Disability