Article
Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function.
JAMA psychiatry - 1 Oct 2017
Smeland Olav B, Frei Oleksandr, Kauppi Karolina, Hill W David, Li Wen, Wang Yunpeng, Krull Florian, Bettella Francesco, Eriksen Jon A, Witoelar Aree, Davies Gail, Fan Chun C, Thompson Wesley K, Lam Max, Lencz Todd, Chen Chi-Hua, Ueland Torill, Jönsson Erik G, Djurovic Srdjan, Deary Ian J, Dale Anders M, Andreassen Ole A
Abstract excerpt
Importance: Schizophrenia is associated with widespread cognitive impairments. Although cognitive deficits are one of the factors most strongly associated with functional outcome in schizophrenia, current treatment strategies largely fail to ameliorate these impairments. To develop more efficient treatment strategies in patients with schizophrenia, a better understanding of the pathogenesis of these cognitive...
Topics
- Adult
- Cognition
- Cognitive Dysfunction
- Female
- GTPase-Activating Proteins
- Genetic Loci
- Genetic Variation
- Genome-Wide Association Study