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Article

Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia.

Schizophrenia research - 1 Nov 2018

Nakahara Soichiro, Medland Sarah, Turner Jessica A, Calhoun Vince D, Lim Kelvin O, Mueller Bryon A, Bustillo Juan R, O'Leary Daniel S, Vaidya Jatin G, McEwen Sarah, Voyvodic James, Belger Aysenil, Mathalon Daniel H, Ford Judith M, Guffanti Guia, Macciardi Fabio, Potkin Steven G, van Erp Theo G M

Abstract excerpt

This study assessed genetic contributions to six cognitive domains, identified by the MATRICS Cognitive Consensus Battery as relevant for schizophrenia, cognition-enhancing, clinical trials. Psychiatric Genomics Consortium Schizophrenia polygenic risk scores showed significant negative correlations with each cognitive domain. Genome-wide association analyses identified loci associated with attention/vigilance...

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Identifiers

PMID: 29907492
DOI: 10.1016/j.schres.2018.05.041
PMCID: PMC6252137

Genes

HDAC9
NDUFS4

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