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Article

Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma.

Blood - 1 Oct 2004

Skibola Christine F, Forrest Matthew S, Coppedé Fabio, Agana Luz, Hubbard Alan, Smith Martyn T, Bracci Paige M, Holly Elizabeth A

Abstract excerpt

Folate metabolism plays an essential role in DNA synthesis and methylation processes. Deviations in the flux of folate due to genetic variation could result in selective growth and genomic instability and affect susceptibility to various cancers including lymphoma. To test this hypothesis, genetic polymorphisms in the folate metabolic pathway were investigated using DNA from a population-based case-control study...

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Topics

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Folic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycine Hydroxymethyltransferase

Share to Lymphoma, Non-Hodgkin

Share to Models, Biological

Share to Odds Ratio

Share to Thymidylate Synthase

Source

Identifiers

PMID: 15198953
DOI: 10.1182/blood-2004-02-0557

Genes

TYMS
MTHFR
MTR
SHMT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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