Article
Risk of non-Hodgkin lymphoma associated with polymorphisms in folate-metabolizing genes.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2005
Lightfoot Tracy J, Skibola Christine F, Willett Eleanor V, Skibola Danica R, Allan James M, Coppede Fabio, Adamson Peter J, Morgan Gareth J, Roman Eve, Smith Martyn T
Abstract excerpt
Genetic instability, including chromosomal imbalance, is important in the pathogenesis of lymphoproliferative disorders such as non-Hodgkin lymphoma (NHL). DNA synthesis and methylation, which are closely linked to folate metabolism and transport, may be affected by polymorphisms in genes involved in these pathways. Folate metabolism polymorphisms have been linked to acute lymphoblastic leukemia and colorectal...
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