Methylenetetrahydrofolate reductase gene polymorphisms (677C > T and 1298A > C) in Egyptian patients with non-Hodgkin lymphoma.

doi:10.4103/0973-1482.103512

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Article

Methylenetetrahydrofolate reductase gene polymorphisms (677C > T and 1298A > C) in Egyptian patients with non-Hodgkin lymphoma.

Journal of cancer research and therapeutics - 1 Jan 2000

Nasr Aml S, Sami Rania M, Ibrahim Noha Y

Abstract excerpt

BACKGROUND: Folate metabolism plays an essential role in Deoxyribonucleic acid (DNA) synthesis and methylation processes. Deviations in the flux of the folate may affect the susceptibility to various cancers including lymphoma. AIM: The aim of this study was to investigate the genetic polymorphisms in 5, 10-methylenetetrahydrofolate reductase (MTHFR 677C/T and 1298A/C) and to evaluate its associations with the...

Topics

Adult
Aged
Egypt
Female
Folic Acid
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
Lymphoma, Large B-Cell, Diffuse

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoma, Non-Hodgkin

Male

Methylenetetrahydrofolate Reductase (NADPH2)

Middle Aged

Polymorphism, Restriction Fragment Length

Polymorphism, Single Nucleotide

Risk

Source

Open in PubMed

Identifiers

PMID: 23174714
DOI: 10.4103/0973-1482.103512

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23174714-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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