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Article

CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70.

Journal of neurochemistry - 1 Jul 2004

Urushitani Makoto, Kurisu Junko, Tateno Minako, Hatakeyama Shigetsugu, Nakayama Kei-Ichi, Kato Shinsuke, Takahashi Ryosuke

Abstract excerpt

Over 100 mutants in superoxide dismutase 1 (SOD1) are reported in familial amyotrophic lateral sclerosis (ALS). However, the precise mechanism by which they are degraded through a ubiquitin-proteasomal pathway (UPP) remains unclear. Here, we report that heat-shock protein (Hsp) or heat-shock cognate (Hsc)70, and the carboxyl terminus of the Hsc70-interacting protein (CHIP), are involved in proteasomal degradation...

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Identifiers

PMID: 15198682
DOI: 10.1111/j.1471-4159.2004.02486.x

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70.PMID 15198682Read ↗

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