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Article

Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase: clues to a possible strategy for treating ALS.

Journal of neurochemistry - 1 Sept 2007

Yamashita Hirofumi, Kawamata Jun, Okawa Katsuya, Kanki Rie, Nakamizo Tomoki, Hatayama Takumi, Yamanaka Koji, Takahashi Ryosuke, Shimohama Shun

Abstract excerpt

A dominant mutation in the gene for copper-zinc superoxide dismutase (SOD1) is the most frequent cause of the inherited form of amyotrophic lateral sclerosis. Mutant SOD1 provokes progressive degeneration of motor neurons by an unidentified acquired toxicity. Exploiting both affinity purification and mass spectrometry, we identified a novel interaction between heat-shock protein 105 (Hsp105) and mutant SOD1. We...

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PMID: 17403032
DOI: 10.1111/j.1471-4159.2007.04534.x

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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