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Article

CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control.

Molecular and cellular biology - 1 Jun 2008

Min Jin-Na, Whaley Ryan A, Sharpless Norman E, Lockyer Pamela, Portbury Andrea L, Patterson Cam

Abstract excerpt

During the course of biological aging, there is a gradual accumulation of damaged proteins and a concomitant functional decline in the protein degradation system. Protein quality control is normally ensured by the coordinated actions of molecular chaperones and the protein degradation system that collectively help to maintain protein homeostasis. The carboxyl terminus of Hsp70-interacting protein (CHIP), a...

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Identifiers

PMID: 18411298
DOI: 10.1128/MCB.00296-08
PMCID: PMC2423116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control.PMID 18411298Read ↗

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