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Article

SOD1-interacting proteins: Roles of aggregation cores and protein degradation systems.

Neuroscience research - 1 Sept 2021

Une Mio, Yamakawa Miho, Watanabe Yasuhiro, Uchino Kazuyuki, Honda Naoto, Adachi Mayuka, Nakanishi Mami, Umezawa Akihiro, Kawata Yasushi, Nakashima Kenji, Hanajima Ritsuko

Abstract excerpt

Cu/Zn superoxide dismutase (SOD1) mutations are associated with amyotrophic lateral sclerosis (ALS). SOD1-positive aggregates in motor neurons, as well as proteins that interact with the aggregates are presumably involved in ALS neurotoxicity. We used a proteomics approach to compare differences in protein expression in spinal cord homogenates from non-transgenic (NTG) and ALS model mice. Using the homogenates,...

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Identifiers

PMID: 32726594
DOI: 10.1016/j.neures.2020.07.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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