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Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction.

Biochemical and biophysical research communications - 31 Mar 2006

Goswami Anand, Dikshit Priyanka, Mishra Amit, Mulherkar Shalaka, Nukina Nobuyuki, Jana Nihar Ranjan

Abstract excerpt

Huntington's disease (HD) is a familial neurodegenerative disorder caused by an abnormal expansion of CAG repeats in the coding region of huntingtin gene. A major hallmark of HD is the proteolytic production of N-terminal fragments of huntingtin containing polyglutamine repeats that form ubiquitinated aggregates in the nucleus and cytoplasm of the affected neurons. However, the mechanism by which the mutant...

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Identifiers

PMID: 16472774
DOI: 10.1016/j.bbrc.2006.01.136

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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