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Disease-associated mutations in C-terminus of HSP70 interacting protein (CHIP) impair its ability to negatively regulate mitophagy.

Neurobiology of disease - 1 Oct 2024

Earnshaw Rebecca, Zhang Yu Tong, Heymann Gregory, Fujisawa Kazuko, Hui Sarah, Kapadia Minesh, Kalia Lorraine V, Kalia Suneil K

Abstract excerpt

C-terminus of HSP70 interacting protein (CHIP) is an E3 ubiquitin ligase and HSP70 cochaperone. Mutations in the CHIP encoding gene are the cause of two neurodegenerative conditions: spinocerebellar ataxia autosomal dominant type 48 (SCA48) and autosomal recessive type 16 (SCAR16). The mechanisms underlying CHIP-associated diseases are currently unknown. Mitochondrial dysfunction, specifically dysfunction in...

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PMID: 39117117
DOI: 10.1016/j.nbd.2024.106625

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