Article
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation.
Human molecular genetics - 1 Apr 2004
Petrucelli Leonard, Dickson Dennis, Kehoe Kathryn, Taylor Julie, Snyder Heather, Grover Andrew, De Lucia Michael, McGowan Eileen, Lewis Jada, Prihar Guy, Kim Jungsu, Dillmann Wolfgang H, Browne Susan E, Hall Alexis, Voellmy Richard, Tsuboi Yoshio, Dawson Ted M, Wolozin Benjamin, Hardy John, Hutton Mike
Abstract excerpt
Molecular chaperones, ubiquitin ligases and proteasome impairment have been implicated in several neurodegenerative diseases, including Alzheimer's and Parkinson's disease, which are characterized by accumulation of abnormal protein aggregates (e.g. tau and alpha-synuclein respectively). Here we report that CHIP, an ubiquitin ligase that interacts directly with Hsp70/90, induces ubiquitination of the microtubule...
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