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Article

Hsp104 is essential for the selective degradation in yeast of polyglutamine expanded ataxin-1 but not most misfolded proteins generally.

Biochemical and biophysical research communications - 1 Jan 2010

Lee Do Hee, Goldberg Alfred L

Abstract excerpt

Molecular chaperones of the Hsp70/40 family protect against the accumulation of mutated or misfolded proteins in part by facilitating their degradation. In the polyglutamine (polyQ) diseases, mutant proteins containing expanded polyQ repeats accumulate in intracellular inclusions and cause neurodegeneration. Although the ubiquitin-proteasome system and chaperones all help protect against accumulation of such...

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Identifiers

PMID: 19995551
DOI: 10.1016/j.bbrc.2009.12.018
PMCID: PMC3779135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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