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Article

Deregulation of cyclin E in human cells interferes with prereplication complex assembly

14 Jun 2004

Abstract excerpt

Deregulation of cyclin E expression has been associated with a broad spectrum of human malignancies. Analysis of DNA replication in cells constitutively expressing cyclin E at levels similar to those observed in a subset of tumor-derived cell lines indicates that initiation of replication and possibly fork movement are severely impaired. Such cells show a specific defect in loading of initiator proteins Mcm4,...

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PMID: 15197178
DOI: 10.1083/jcb.200404092

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