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Article

Cyclin E overexpression impairs progression through mitosis by inhibiting APCCdh1

30 Jul 2007

Abstract excerpt

Overexpression of cyclin E, an activator of cyclin-dependent kinase 2, has been linked to human cancer. In cell culture models, the forced expression of cyclin E leads to aneuploidy and polyploidy, which is consistent with a direct role of cyclin E overexpression in tumorigenesis. In this study, we show that the overexpression of cyclin E has a direct effect on progression through the latter stages of mitotic...

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PMID: 17664332
DOI: 10.1083/jcb.200703202

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