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Article

Chromosomal instability and lack of cyclin E regulation in hCdc4 mutant human breast cancer cells.

Breast cancer research : BCR - 1 Jan 2004

Willmarth Nicole E, Albertson Donna G, Ethier Stephen P

Abstract excerpt

INTRODUCTION: Cyclin E, a G1 cyclin essential for G1-S phase transition, is known to have a profound effect on tumorigenesis. Elevated levels of cyclin E have been associated with breast cancer, and chromosomal instability observed in breast cancer is suggested to be associated with constitutive expression of cyclin E. It was previously demonstrated that SUM149PT human breast cancer cells show very high levels of...

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Identifiers

PMID: 15318934
DOI: 10.1186/bcr900
PMCID: PMC549168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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