Article

Quantitative Profiling of Adaptation to Cyclin E Overproduction

2021-07-26

Abstract excerpt

<h4>ABSTRACT</h4> Cyclin E/CDK2 drives cell cycle progression from G1 to S phase. Cyclin E overproduction is toxic to mammalian cells, although the gene encoding cyclin E ( CCNE1 ) is overexpressed in some cancers. To gain insight into how cancer cells tolerate high cyclin E, we extensively characterized non-transformed epithelial cells throughout a time course of chronic cyclin E overproduction. Cells overprodu...

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Literature Corpus work: e5d58daa-8b1b-545a-987c-e8065a98fb70
DOI: 10.1101/2021.07.26.453751

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