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Article

Replication licensing promotes cyclin D1 expression and G<sub>1</sub>progression in untransformed human cells

1 Jan 2009

Abstract excerpt

Defects in DNA replication are implicated as early and causal events in malignancy. However, the immediate effects of impaired DNA replication licensing on cell cycle progression of non-malignant human cells are unknown. Therefore, we have investigated the acute effects of Mcm7 ablation using synchronized cultures of untransformed Human Dermal Fibroblasts (HDF). Mcm7 ablation elicited a G(1) delay associated with...

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PMID: 19106611
DOI: 10.4161/cc.8.1.7528

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