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Article

dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development.

Molecular cell - 1 Mar 2001

Ceol C J, Horvitz H R

Abstract excerpt

The synthetic multivulva (synMuv) genes define two functionally redundant pathways that antagonize RTK/Ras signaling during Caenorhabditis elegans vulval induction. The synMuv gene lin-35 encodes a protein similar to the mammalian tumor suppressor pRB and has been proposed to act as a transcriptional repressor. Studies using mammalian cells have shown that pRB can prevent cell cycle progression by inhibiting...

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PMID: 11463372
DOI: 10.1016/s1097-2765(01)00194-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development.PMID 11463372Read ↗

Identification and classification of genes that act antagonistically to let-60 Ras signaling in Caenorhabditis elegans vulval development.Semantic proximity Read ↗

lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.Semantic proximity Read ↗

Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex.Semantic proximity Read ↗

C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates.Semantic proximity Read ↗

Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans.Semantic proximity Read ↗

Caenorhabditis elegans lin-13, a member of the LIN-35 Rb class of genes involved in vulval development, encodes a protein with zinc fingers and an LXCXE motif.Semantic proximity Read ↗

SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegans.Semantic proximity Read ↗

Promotion of oogenesis and embryogenesis in theC. elegansgonad by EFL-1/DPL-1 (E2F) does not require LIN-35 (pRB)Semantic proximity Read ↗

Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity.Semantic proximity Read ↗

A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling.Semantic proximity Read ↗

New genes that interact with lin-35 Rb to negatively regulate the let-60 ras pathway in Caenorhabditis elegans.Semantic proximity Read ↗

LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes.Semantic proximity Read ↗

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