Article
Matrix metalloproteinase-9 genotype influences large artery stiffness through effects on aortic gene and protein expression.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2004
Medley Tanya L, Cole Timothy J, Dart Anthony M, Gatzka Christoph D, Kingwell Bronwyn A
Abstract excerpt
OBJECTIVE: Because large artery stiffening contributes to myocardial ischemia, its determinants are of relevance as potential risk markers. This study examined whether matrix metalloproteinase (MMP)-9 (gelatinase B) genotype is associated with large artery stiffening and aortic MMP-9 gene and protein expression. METHODS AND RESULTS: MMP-9 genotype (C-1562T promoter polymorphism) was determined in 84 patients (73...
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