Article
Fibrillin-1 genotype is associated with aortic stiffness and disease severity in patients with coronary artery disease.
Circulation - 19 Feb 2002
Medley Tanya L, Cole Timothy J, Gatzka Christoph D, Wang William Y S, Dart Anthony M, Kingwell Bronwyn A
Abstract excerpt
BACKGROUND: Elevated pulse pressure is associated strongly with adverse cardiovascular outcome; however, the genetic basis of this condition is unknown. This study examined whether genotypic variation in the extracellular matrix protein fibrillin-1, the Marfan gene, was associated with aortic stiffening and therefore could contribute to cardiovascular risk associated with pulse pressure elevation in coronary...
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