Article
Variation in the human matrix metalloproteinase-9 gene is associated with arterial stiffness in healthy individuals.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2006
Yasmin, McEniery Carmel M, O'Shaughnessy Kevin M, Harnett Patrick, Arshad Asif, Wallace Sharon, Maki-Petaja Kaisa, McDonnell Barry, Ashby Mike J, Brown John, Cockcroft John R, Wilkinson Ian B
Abstract excerpt
BACKGROUND: Arterial stiffness is an important determinant of cardiovascular risk. Elastin is the main elastic component of the arterial wall and can be degraded by a number of enzymes including serine proteases and matrix metalloproteinases (MMPs). Serum MMP-9 levels correlate with arterial stiffness and predict cardiovascular risk. Polymorphisms in the MMP-9 gene are also associated with large artery function...
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