Article
A single nucleotide polymorphism in the matrix metalloproteinase 9 gene (-8202A/G) is associated with thoracic aortic aneurysms and thoracic aortic dissection.
The Journal of thoracic and cardiovascular surgery - 1 May 2006
Chen Li, Wang Xinwen, Carter Stacey A, Shen Ying H, Bartsch Heather R, Thompson Robert W, Coselli Joseph S, Wilcken David L, Wang Xing Li, LeMaire Scott A
Abstract excerpt
OBJECTIVE: Matrix metalloproteinase 9 plays an important role in the maintenance of the aortic extracellular matrix. Genetic variations that affect protease expression or activity might contribute to thoracic aortic disease. The purpose of this study was to determine whether 3 single nucleotide polymorphisms in the matrix metalloproteinase 9 gene are associated with thoracic aortic aneurysms and dissection....
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