Article
Prospective meta-analysis of interleukin 1 gene complex polymorphisms confirms associations with ankylosing spondylitis.
Annals of the rheumatic diseases - 1 Sept 2008
Sims A-M, Timms A E, Bruges-Armas J, Burgos-Vargas R, Chou C-T, Doan T, Dowling A, Fialho R N, Gergely P, Gladman D D, Inman R, Kauppi M, Kaarela K, Laiho K, Maksymowych W, Pointon J J, Rahman P, Reveille J D, Sorrentino R, Tuomilehto J, Vargas-Alarcon G, Wordsworth B P, Xu H, Brown M A
Abstract excerpt
OBJECTIVES: The aim of the current study was to determine the contribution of interleukin (IL)1 gene cluster polymorphisms previously implicated in susceptibility for ankylosing spondylitis (AS) to AS susceptibility in different populations worldwide. METHODS: Nine polymorphisms in the IL1 gene cluster members IL1A (rs2856836, rs17561 and rs1894399), IL1B (rs16944), IL1F10 (rs3811058) and IL1RN (, the...