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Directed evolution of a single-chain class II MHC product by yeast display

1 Feb 2003

Abstract excerpt

Many autoimmune diseases have been linked to the class II region of the major histocompatibility complex (MHC). The linkage is thought to be a result of autoreactive T cells that recognize self-peptides bound to a product of this locus. For example, T cells from non-obese diabetic mice recognize specific 'diabetogenic' peptides bound to a class II MHC allele called I-A(g7). The I-A(g7) molecule is noted for being...

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PMID: 12676983
DOI: 10.1093/proeng/gzg018

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