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Article

Association of aldehyde dehydrogenase-2 polymorphism with alcoholic polyneuropathy in humans.

Neuroscience letters - 17 Jun 2004

Masaki Toshihiro, Mochizuki Hitoshi, Matsushita Sachio, Yokoyama Akira, Kamakura Keiko, Higuchi Susumu

Abstract excerpt

Persons who have the Glu-487-->Lys mutation (single nucleotide polymorphism) of the aldehyde dehydrogenase-2 (ALDH2) gene have less ability to metabolize the alcohol breakdown product acetaldehyde. In order to clarify whether acetaldehyde is associated with the pathogenesis of alcoholic polyneuropathy, we compared nerve conduction data as well as clinical signs and symptoms of neuropathy between alcoholics with...

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Source

Identifiers

PMID: 15182962
DOI: 10.1016/j.neulet.2004.04.009

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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