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Article

Association Between Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism and Alcoholic Liver Disease.

The American journal of the medical sciences - 1 Jul 2018

Chang Binxia, Hao Shuli, Zhang Longyu, Gao Miaomiao, Sun Ying, Huang Ang, Teng Guangju, Li Baosen, Crabb David W, Kusumanchi Praveen, Wang Li, Liangpunsakul Suthat, Zou Zhengsheng

Abstract excerpt

BACKGROUND: Only a subset of patients with excessive alcohol use develop alcoholic liver disease (ALD), though the exact mechanism is not completely understood. Once ingested, alcohol is metabolized by 2 key oxidative enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). There are 2 major ALDH isoforms, cytosolic and mitochondrial, encoded by the aldehyde ALDH1 and ALDH2 genes, respectively. The...

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Share to Aldehyde Dehydrogenase, Mitochondrial
Share to Amino Acid Substitution

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genetic Predisposition to Disease

Share to Liver Cirrhosis, Alcoholic

Share to Mutation, Missense

Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 29779728
DOI: 10.1016/j.amjms.2018.03.012
PMCID: PMC6063768

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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