Genetic polymorphisms of alcohol metabolizing enzymes related to alcohol sensitivity and alcoholic diseases.

Article

Genetic polymorphisms of alcohol metabolizing enzymes related to alcohol sensitivity and alcoholic diseases.

Alcohol and alcoholism (Oxford, Oxfordshire) - 1 Nov 1994

Yoshida A

Abstract excerpt

Individuals with the atypical aldehyde dehydrogenase ALDH2 allele, both homozygous and heterozygous status, are alcohol sensitive and have a markedly reduced risk of developing alcoholic diseases. Genetic abnormalities of the ALDH1 locus are also associated with alcohol flushing. The ALDH3 and AL...

Topics

Alcoholism
Aldehyde Dehydrogenase
Alleles
Ethanol
Female
Flushing
Genetic Carrier Screening
Homozygote
Humans
Isoenzymes
Japan
Liver Diseases, Alcoholic
Male
Polymorphism, Genetic
Risk Factors

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