Article
Natural variation in the npr-1 gene modifies ethanol responses of wild strains of C. elegans.
Neuron - 10 Jun 2004
Davies Andrew G, Bettinger Jill C, Thiele Tod R, Judy Meredith E, McIntire Steven L
Abstract excerpt
Variation in the acute response to ethanol between individuals has a significant impact on determining susceptibility to alcoholism. The degree to which genetics contributes to this variation is of great interest. Here we show that allelic variation that alters the functional level of NPR-1, a neuropeptide Y (NPY) receptor-like protein, can account for natural variation in the acute response to ethanol in wild...
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