Back to search

Article

Natural variation in protein kinase D modifies alcohol sensitivity in <i>Caenorhabditis elegans</i>

2024-06-09

Abstract excerpt

Differences in naïve alcohol sensitivity among individuals are a strong predictor of later-life alcohol use disorders (AUD). However, the genetic bases of alcohol sensitivity (beyond ethanol metabolism) and pharmacological approaches to modulate alcohol sensitivity remain poorly understood. We used a high-throughput behavioral screen to measure acute behavioral sensitivity to alcohol, a model of intoxication, in a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
62559ea7-1b24-52e3-8645-b337bb29b540
DOI
10.1101/2024.06.09.598102
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Natural variation in protein kinase D modifies alcohol sensitivity in <i>Caenorhabditis elegans</i>DOI 10.1101/2024.06.09.598102
DrosophilaandCaenorhabditis elegansas Discovery Platforms for Genes Involved in Human Alcohol Use DisorderSemantic proximity
Functional validity, role, and implications of heavy alcohol consumption genetic loci.Semantic proximity
Natural variation suggests candidate genes underlying <i>Caenorhabditis elegans</i> susceptibility to diverse toxicantsSemantic proximity
Polymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult drosophila.Semantic proximity
Evidence for Involvement of <i>WDPCP</i> Gene in Alcohol Consumption, Lipid Metabolism, and Liver CirrhosisSemantic proximity
Natural variation suggests candidate genes underlying Caenorhabditis elegans susceptibility to diverse toxicants.Semantic proximity
Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster.Semantic proximity
Natural variation in <i>C. elegans</i> arsenic toxicity is explained by differences in branched chain amino acid metabolismSemantic proximity
Caenorhabditis elegans as a platform for molecular quantitative genetics and the systems biology of natural variation.Semantic proximity
Genetics of alcohol consumption in Drosophila melanogaster.Semantic proximity
Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms.Semantic proximity
From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation.Semantic proximity
Select a neighboring publication to make it the new centre.