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Article

A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology.

PLoS genetics - 1 Feb 2014

Andersen Erik C, Bloom Joshua S, Gerke Justin P, Kruglyak Leonid

Abstract excerpt

The mechanistic basis for how genetic variants cause differences in phenotypic traits is often elusive. We identified a quantitative trait locus in Caenorhabditis elegans that affects three seemingly unrelated phenotypic traits: lifetime fecundity, adult body size, and susceptibility to the human pathogen Staphyloccus aureus. We found a QTL for all three traits arises from variation in the neuropeptide receptor...

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Identifiers

PMID: 24586193
DOI: 10.1371/journal.pgen.1004156
PMCID: PMC3937155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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