A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans.

doi:10.1126/science.1166527

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Article

A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans.

Science (New York, N.Y.) - 16 Jan 2009

Reddy Kirthi C, Andersen Erik C, Kruglyak Leonid, Kim Dennis H

Abstract excerpt

The nematode Caenorhabditis elegans responds to pathogenic bacteria with conserved innate immune responses and pathogen avoidance behaviors. We investigated natural variation in C. elegans resistance to pathogen infection. With the use of quantitative genetic analysis, we determined that the pathogen susceptibility difference between the laboratory wild-type strain N2 and the wild isolate CB4856 is caused by a...

Topics

Animals
Behavior, Animal
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cues
Genes, Helminth
Immunity, Innate
Movement
Mutation
Oxygen
Polymorphism, Genetic
Pseudomonas aeruginosa
Receptors, Neuropeptide Y

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Identifiers

PMID: 19150845
DOI: 10.1126/science.1166527
PMCID: PMC2748219

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