Article
A novel cholinergic action of alcohol and the development of tolerance to that effect in Caenorhabditis elegans.
Genetics - 1 Jan 2015
Hawkins Edward G, Martin Ian, Kondo Lindsay M, Judy Meredith E, Brings Victoria E, Chan Chung-Lung, Blackwell GinaMari G, Bettinger Jill C, Davies Andrew G
Abstract excerpt
Understanding the genes and mechanisms involved in acute alcohol responses has the potential to allow us to predict an individual's predisposition to developing an alcohol use disorder. To better understand the molecular pathways involved in the activating effects of alcohol and the acute functional tolerance that can develop to such effects, we characterized a novel ethanol-induced hypercontraction response...
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