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Article

The Drosophila F box protein archipelago regulates dMyc protein levels in vivo.

Current biology : CB - 8 Jun 2004

Moberg Kenneth H, Mukherjee Ashim, Veraksa Alexey, Artavanis-Tsakonas Spyros, Hariharan Iswar K

Abstract excerpt

BACKGROUND: The Myc oncoprotein is an important regulator of cellular growth in metazoan organisms. Its levels and activity are tightly controlled in vivo by a variety of mechanisms. In normal cells, Myc protein is rapidly degraded, but the mechanism of its degradation is not well understood. RESULTS: Here we present genetic and biochemical evidence that Archipelago (Ago), the F box component of an SCF-ubiquitin...

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Identifiers

PMID: 15182669
DOI: 10.1016/j.cub.2004.04.040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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