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Article

Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye.

Development (Cambridge, England) - 1 Jan 2011

Nicholson Sarah C, Nicolay Brandon N, Frolov Maxim V, Moberg Kenneth H

Abstract excerpt

archipelago (ago)/Fbw7 encodes a conserved protein that functions as the substrate-receptor component of a polyubiquitin ligase that suppresses tissue growth in flies and tumorigenesis in vertebrates. Ago/Fbw7 targets multiple proteins for degradation, including the G1-S regulator Cyclin E and the oncoprotein dMyc/c-Myc. Despite prominent roles in growth control, little is known about the signals that regulate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21148181
DOI: 10.1242/dev.054429
PMCID: PMC3005602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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