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Article

The tumor suppressor archipelago E3 ligase is required for spermatid differentiation in Drosophila testis.

Scientific reports - 19 Apr 2021

Vedelek Viktor, Kovács Attila L, Juhász Gábor, Alzyoud Elham, Sinka Rita

Abstract excerpt

The human orthologue of the tumor suppressor protein FBW7 is encoded by the Drosophila archipelago (ago) gene. Ago is an F-box protein that gives substrate specificity to its SCF ubiquitin ligase complex. It has a central role in multiple biological processes in a tissue-specific manner such as cell proliferation, cellular differentiation, hypoxia-induced gene expression. Here we present a previously unknown...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33875704
DOI: 10.1038/s41598-021-87656-3
PMCID: PMC8055871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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