Article
Infrequent mutations of Archipelago (hAGO, hCDC4, Fbw7) in primary ovarian cancer.
Gynecologic oncology - 1 Jul 2005
Kwak Eunice L, Moberg Kenneth H, Wahrer Doke C R, Quinn Jennifer E, Gilmore Paula M, Graham Colin A, Hariharan Iswar K, Harkin D Paul, Haber Daniel A, Bell Daphne W
Abstract excerpt
OBJECTIVE: Archipelago (AGO, also known as hCdc4, Fbw7, or Sel-10) is an F-box containing component of the SCF complex implicated in the ubiquitination and proteolysis of cyclin E and c-Myc, and found to be mutated in 16% of endometrial carcinomas. We have previously reported somatic mutations in AGO in 3/10 ovarian cancer cell lines, but the frequency of such mutations in primary ovarian cancer is unknown....
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