Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype.

doi:10.1073/pnas.94.4.1235

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Article

Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 18 Feb 1997

Schreiber-Agus N, Stein D, Chen K, Goltz J S, Stevens L, DePinho R A

Abstract excerpt

Biochemical and biological activities of Myc oncoproteins are highly dependent upon their association with another basic region helix-loop-helix/leucine zipper (bHLH/LZ) protein, Max. Our previous observation that the DNA-binding/dimerization region of Max is absolutely conserved throughout verte...

Topics

Amino Acid Sequence
Animals
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Basic-Leucine Zipper Transcription Factors
Cell Differentiation
Cell Transformation, Neoplastic
Cells, Cultured
DNA-Binding Proteins
Drosophila
Fibroblasts
Genes, myc
Helix-Loop-Helix Motifs
Mitosis
Molecular Sequence Data

Source

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Identifiers

PMID: 9037036
DOI: 10.1073/pnas.94.4.1235
PMCID: PMC19774

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9037036-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Phenotype

Protein Binding

Proto-Oncogene Proteins c-myc

Rats